itmeanscourage: (Default)

[personal profile] itmeanscourage 2022-03-14 08:33 pm (UTC)(link)
Isamu was startled at first by the frank first-hand description of such behavior, but remained stoic. This was still a scientific discussion after all. And he found himself glancing at the place setting, even though the server had taken away both their plates and silverware by this point.

“Those aforementioned structural abnormalities, hyperactivity in certain portions of the hippocampus and amygdala, and potential underactivation of thalamic areas involved in pain, would be quite the combination.” He agreed, though not with a tone that would suggest he thought Rekker was broken. “Quite the case study.”

itmeanscourage: (thoughtful)

[personal profile] itmeanscourage 2022-03-14 11:07 pm (UTC)(link)
“I do not mean to suggest that you do not feel it. I should have specified that I was not referring merely to the sensory processing of pain intensity. There is compelling evidence to suggest the affective processing of pain - its unpleasantness - may be different in individuals who participate in self-harming behaviors.” He corrected himself. “Not to mention the fact that pain is modulated by contextual stimuli, such as emotions, social factors or other perceptions.”

And that didn’t even begin to analyze the potential role of abnormal feedback in the striatal dopamine system, or dysfunctions of the hypothalamic-pituitary-adrenal axis and its altered secretion of stress hormones and affect on serotonin.
itmeanscourage: (Default)

[personal profile] itmeanscourage 2022-03-15 12:03 pm (UTC)(link)
“I dare say wires being crossed is quite an appropriate metaphor, as fMRI studies have documented masochists activating brain areas involved in sensory processing rather than affective pain processing when they receive painful stimuli within that particular context.” He nodded. “But through involvement of the parietal operculum, which suggests additional cognitive evaluation, not the ventral striatum, which would suggest the processing of rewards.”

In other words, it was less about pleasure and more about memory and cognitive reevaluation. Which seemed to fit with Rekker’s desire to remain in control of his pain. At least partially.
itmeanscourage: (thoughtful)

[personal profile] itmeanscourage 2022-03-17 12:01 pm (UTC)(link)
That revelation made Isamu pause.

“Hmm… That runs counter to what a number of studies have found, but that does not mean it cannot be ruled out. After all, opioid and dopaminergic systems and the HPA axis can both be activated either by psychoactive drugs or by behaviors. So it is still plausible that for a subset of cases, the same biological mechanisms support the development of addiction as well as self-harming behaviors.”

Comorbidity at its finest. Wires getting crossed.
itmeanscourage: (shocked)

[personal profile] itmeanscourage 2022-03-19 01:31 am (UTC)(link)
Isamu’s eyes widened for a moment, though he felt no need to ask for clarification. He could easily read between the lines, and scoffed a hasty, “whatever releases dopamine in your nucleus accumbens, I suppose…”

That sort of thing was not a turn-on for the scientist. And unfortunately, very little scientific literature actually existed on that particular subject to fill in the gaps.