“I do not mean to suggest that you do not feel it. I should have specified that I was not referring merely to the sensory processing of pain intensity. There is compelling evidence to suggest the affective processing of pain - its unpleasantness - may be different in individuals who participate in self-harming behaviors.” He corrected himself. “Not to mention the fact that pain is modulated by contextual stimuli, such as emotions, social factors or other perceptions.”

And that didn’t even begin to analyze the potential role of abnormal feedback in the striatal dopamine system, or dysfunctions of the hypothalamic-pituitary-adrenal axis and its altered secretion of stress hormones and affect on serotonin.